Zopiclone (Imovane) is indicated for the short-term treatment and symptomatic reduction of insomnia characterized by problem in falling asleep, frequent nocturnal awakenings and/or early morning awakenings.
Treatment with zopiclone ought to often not exceed 7-10 consecutive days. Use for more than 2-3 consecutive weeks requires full re-evaluation of the affected person. Prescriptions for zopiclone must be written for short-term use (7-10 days) and it shouldn’t be prescribed in quantities exceeding a 1-month provide.
The use of hypnotics should be restricted for insomnia the place disturbed sleep ends in impaired daytime functioning.
Dosage and administration:
Imovane should only be taken when you are in a position to get a full night’s sleep (7 to 8 hours) earlier than you should be active once more.
The commonplace adult dose of zopiclone is one pill simply earlier than you go to bed.
This medicine must be taken in a single consumption and not readministered during the identical evening.
If you are over 65 years of age the dose is half a tablet taken simply before you go to bed.
If you may have a liver or kidney downside, the same old really helpful dose is half a pill taken just earlier than you go to bed.
Overdosage:
Signs and signs:
Overdose by zopiclone drugs is normally manifested by varying levels of central nervous system depression starting from drowsiness to coma based on the quantity ingested. In mild circumstances, symptoms embrace drowsiness, confusion, and lethargy; in additional severe cases, symptoms might embrace ataxia, hypotonia, hypotension, methaemoglobinaemia, respiratory despair, and coma. Overdose shouldn’t be life threatening except mixed with different CNS depressants, together with alcohol. Other threat factors, such because the presence of concomitant sickness and the debilitated state of the affected person, could contribute to the severity of signs and really hardly ever can lead to deadly outcome.
In voluntary or unintentional instances of zopiclone overdosage involving doses as a lot as 340 mg, the principal results reported have been prolonged sleep, drowsiness, lethargy and ataxia.
Recommended therapy:
Symptomatic and supportive treatment in sufficient clinical setting is recommended, attention should be paid to respiratory and cardiovascular capabilities. Gastric lavage or activated charcoal is only useful when carried out soon after ingestion.
Hemodialysis is of no value as a end result of large volume of distribution of zopiclone. Flumazenil could also be a helpful antidote; nevertheless, flumazenil administration may contribute to the appearance of neurological symptoms (agitation, nervousness, convulsionsand emotional lability). Intravenous fluids must be administered as needed.